{"id":16173,"date":"2022-06-14T14:19:59","date_gmt":"2022-06-14T12:19:59","guid":{"rendered":"https:\/\/cienciagandia.webs.upv.es\/?p=16173"},"modified":"2022-06-14T14:34:08","modified_gmt":"2022-06-14T12:34:08","slug":"desafiant-la-maleida-trucada","status":"publish","type":"post","link":"https:\/\/cienciagandia.webs.upv.es\/ca\/2022\/06\/desafiant-la-maleida-trucada\/","title":{"rendered":"Desafiant la male\u00efda trucada"},"content":{"rendered":"

Imagina’t que un dia reps una trucada de les quals mai voldries rebre: un familiar directe ha mort. De sobte. Podria ser un oncle o una tia amb el qual tens m\u00e9s o menys tracte. Per\u00f2 b\u00e9 podria tractar-se de la teua mare o el teu pare. Potser una germana. O el teu fill de 21 anys mentre entrenava. Despr\u00e9s et conten que patia una cardiopatia no detectada. I que \u00e9s heredit\u00e0ria. \u00c9s a dir, que potser tamb\u00e9 la pateixes tu. I encara no ho saps. I fins i tot et podria haver tocat abans a tu. La Unitat de Cardiopaties Familiars de l’Hospital La Fe de Val\u00e8ncia, encap\u00e7alada per la cardi\u00f2loga (i ja puc dir que amiga) Esther Zorio, realitza el seguiment i tractament de pacients amb cardiopaties heredit\u00e0ries amb el risc de mort sobtada. Puc dir que estan en les millors mans. A m\u00e9s, la Dra. Zorio dirigeix el grup d’investigaci\u00f3 de Cardiopaties Familiars, Mort Sobtada i Mecanismes de Malaltia de l’Institut d’Investigaci\u00f3 Sanit\u00e0ria La Fe, amb la finalitat de millorar en el coneixement d’aquestes malalties i contribuir aix\u00ed a una reducci\u00f3 de la fatalitat. Des de fa uns anys, arran d’un projecte de col\u00b7laboraci\u00f3 UPV-La Fe, tinc el privilegi de col\u00b7laborar en una l\u00ednia d’investigaci\u00f3 amb ella i el seu equip. Us contar\u00e9 una mica sobre aix\u00f2.<\/p>\n

Una d’aquestes cardiopaties \u00e9s la denominada miocardiopatia arritmog\u00e8nica. Es denomina aix\u00ed perqu\u00e8 \u00e9s molt propensa a desencadenar arr\u00edtmies ventriculars. Algunes d’elles podrien acabar en un episodi de fibril\u00b7laci\u00f3 ventricular. Si no s’actua r\u00e0pidament amb un desfibril\u00b7lador (pot ser externament, o tamb\u00e9 si el pacient porta un desfibril\u00b7lador autom\u00e0tic implantat), el risc de defunci\u00f3 \u00e9s elevad\u00edssim. Aquesta cardiopatia pot donar-se amb afectaci\u00f3 de ventricle dret o d’esquerre (o tots dos). Per a l’afectaci\u00f3 de ventricle esquerre, no hi havia ni tan sols guies per al seu diagn\u00f2stic quan iniciem la col\u00b7laboraci\u00f3, i nom\u00e9s des de fa un any existeix una proposta de criteris. Pot sorprendre que hagen tardat tant i que no hi haja una prova inequ\u00edvoca per al seu diagn\u00f2stic, per\u00f2 hem d\u2019intentar entendre-ho. \u00c9s una miocardiopatia molt complexa i a m\u00e9s \u00e9s una malaltia rara, per la qual cosa resulta dif\u00edcil investigar en aix\u00f2. \u00d2bviament, fa falta un increment en recursos per a fer recerca en aquestes malalties que, encara que no freq\u00fcents a nivell poblacional, el sofriment que produeixen en les fam\u00edlies afectades \u00e9s indescriptible. Una sentida abra\u00e7ada per a totes elles. Des del nostre grup d’investigaci\u00f3 vol\u00edem contribuir a millorar el coneixement respecte del seu diagn\u00f2stic.<\/p>\n

\"\"<\/p>\n

De la m\u00e0 de la meua inestimable col\u00b7laboradora Yolanda Vives, investigadora en el meu grup i ara professora a la Universitat de Val\u00e8ncia, inici\u00e0rem un estudi per a processar i analitzar les seq\u00fc\u00e8ncies d’imatges de resson\u00e0ncia magn\u00e8tica card\u00edaca de pacients afectats i comparar-les amb les d’altres persones no afectades, a les quals denomin\u00e0rem controls. Analitz\u00e0rem detalladament la contracci\u00f3 del ventricle esquerre durant el proc\u00e9s de s\u00edstole. De les nostres observacions es va concloure que alguns dels pacients presentaven una contracci\u00f3 anormal. D’una banda, el ventricle esquerre es deformava en menor grau (menor contracci\u00f3) i a m\u00e9s amb menys sincronia (totes les regions del ventricle no es contreien exactament alhora). Pensem que aquest resultat podia ser valu\u00f3s, per la qual cosa vam procedir a quantificar graus de deformaci\u00f3 i d\u2019asincronia, aix\u00ed com a documentar les regions del ventricle amb contracci\u00f3 an\u00f2mala. Els resultats van ser publicats en International Journal of Cardiology, una revista cient\u00edfica de gran prestigi. I el nostre somni \u00e9s que servisquen d’inspiraci\u00f3 per a establir nous biomarcadors que algun dia puguen ser inclosos en les futures guies per al diagn\u00f2stic d’aquesta miocardiopatia. I aportar aix\u00ed el nostre granet d’arena en un camp tan complex.<\/p>\n

No sabem la sort que tenim a Val\u00e8ncia de comptar amb aquesta unitat i amb l’incansable treball de la Dra. Zorio al costat del seu equip (gr\u00e0cies per tant!) per a tractar d’evitar, en la major mesura del possible, que alg\u00fa haja de despenjar el tel\u00e8fon.<\/p>\n

Aquest treball no seria possible sense la col\u00b7laboraci\u00f3 de l’Institut de Medicina Legal i Ci\u00e8ncies Forenses de Val\u00e8ncia, l’Associaci\u00f3 de Pacients de Cardiopaties Familiars de la CV, l\u2019Institut de Salut Carles III, l’Ag\u00e8ncia Estatal d’Investigaci\u00f3, CIBERCV, Ajudes UPV-IIS La Fe, Associaci\u00f3 Memorial Nacho Barber\u00e0, Agence Nationale de la Recherche, Pfizer Global i Telemarat\u00f3 TV3.<\/p>\n

 <\/p>\n

M\u00e9s informaci\u00f3:<\/p>\n

Vives-Gilabert, Y.; Sanz-S\u00e1nchez, J.; Molina, P.; Cebri\u00e1n Ferriols, AJ.; Igual, B.; Calvillo-Batll\u00e9s, P.; Domingo, D, Millet J, Castells F, Zorio E (2019). Left ventricular myocardial dysfunction in arrhythmogenic cardiomyopathy with left ventricular involvement: A door to improving diagnosis. International Journal of Cardiology. 274:237-244.<\/a><\/p>\n

\n

Francisco Castells Ram\u00f3n<\/a><\/p>\n

Professor Titular de la Universitat Polit\u00e8cnica de Val\u00e8ncia
\nDepartament d’Enginyeria Electr\u00f2nica
\nCampus de Gandia
\nInstitut ITACA<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Imagina’t que un dia reps una trucada de les quals mai voldries rebre: un familiar directe ha mort. De sobte. Podria ser un oncle o … Llegir m\u00e9s<\/a><\/p>\n","protected":false},"author":11,"featured_media":16163,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[248],"tags":[706],"class_list":["post-16173","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-divulgacio","tag-destacat-ca","resize-featured-image"],"yoast_head":"\nDesafiant la male\u00efda trucada - Campus de Gandia Ciencia - UPV Universitat Polit\u00e8cnica de Val\u00e8ncia<\/title>\n<meta name=\"description\" content=\"La Unitat de Cardiopaties Familiars de l'Hospital La Fe de Val\u00e8ncia est\u00e0 encap\u00e7alada per Esther Zorio.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cienciagandia.webs.upv.es\/ca\/2022\/06\/desafiant-la-maleida-trucada\/\" \/>\n<meta property=\"og:locale\" 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